- Produces Ceramides in Skin – unlike other products
- Minimizes Trans-Epidermal Water Loss (TEWL)
- Supple, Healthy Skin; Helps Slow Down Skin Aging Processes
- Excellent Moisturizer for Atopic, Psoriasis and Acne Prone Skin Conditions
Produces Ceramides in Skin – unlike other products
Minimizes Trans-Epidermal Water Loss (TEWL)
Supple, Healthy Skin; Helps Slow Down Skin Aging Processes
Excellent Moisturizer for Atopic, Psoriasis and Acne Prone Skin Conditions
What are CERAMIDES?
Human skin is the largest organ of the body and is an effective physical barrier keeping it protected from environmental challenges.
This barrier function of the skin is based on stratum corneum, located in the uppermost skin. Stratum corneum has corneocytes surrounded by multilamellar lipid membranes which are composed of cholesterol, free fatty acids and ceramides (CERs).
Ceramides are of 9 types, numbered from 1 to 9 based on length of their fatty acid chains and nature of their sphingoid bases.
Decline in Skin CERAMIDE Levels
Ceramide levels decrease significantly, with increasing age. In addition, the stratum corneum lipid levels including ceramides from all the body sites dramatically deplete in winter compared with spring and summer.
Decrease in levels of intercellular lipids and the altered ratios of fatty acids esterified to ceramides, are likely to contribute to the increased susceptibility of aged skin to loss of skin barrier function and xerosis, particularly during the winter months.
CERAMIDES decline in Atopic Dermatitis
Atopic dermatitis (AD) is a chronic, relapsing, inflammatory, pruritic skin disease. Patients with AD have significantly decreased ceramide levels in the stratum corneum. Not only lesional skin, but also non-lesional skin also exhibits marked reduction in ceramides reaching upto 50% drop in ceramide levels. Ceramide 1 which is particularly important for skin permeability barrier function is particularly reduced in Atopic Dermatitis
CERAMIDES decline in Psoriasis
Marked depletion of ceramides especially ceramide 1, 4, & 5 has been reported in patients with psoriasis and the reduction in ceramide is directly related with clinical severity
CERAMIDES Role in Acne
Acne vulgaris (acne) is a multifactorial skin condition with a prolonged course of acute flares and recurrences. Acne is associated with inherent abnormalities in epidermal barrier functions. Moreover, some acne therapies can induce alterations within the epidermis that can lead to changes that disrupt some of the normal physiological functions of the epidermis, including the stratum corneum
CERAMIDES for Baby / Infant Skin
Ceramides represent the third largest fraction (20-23%) of all barrier lipids both in vernix and in fetal skin. In postnatal skin, ceramides are the second largest fraction (24-29%) of barrier lipids. Increase in ceramide concentration is correlated with maturation of the trans-epidermal barrier.
CERAMIDES for Aged Skin
Exogenous ceramides have been part of many anti-wrinkle products. Topical application of exogenous ceramide have very limited benefit, if at all any. CERABEST®, by its endogenous action, is able to generate ceramides in the skin, thus providing an effective natural lipid barrier which can slow down age-related changes in the epidermis
Exogenous Ceramides
Commercial Cosmetics Available with EXOGENOUS ceramides have following Limitations*:
- External / exogenous ceramides are POORLY water soluble
- Ceramides are high molecular weight – Percutaneous absorption of these compounds is very limited when applied topically
- Lastly external ceramides included in commercially available cosmetics are barely of 1, 2 or 3 types and not an entire spectrum of 9 ceramides
CeraBEST®- contains
- DeramaACB® which is an excellent postbiotic metabolite for ENDOGENOUS / In-Vivo production of Ceramides in the skin
- Full spectrum of body’s own Ceramides are produced in the skin
- Quick and faster restoration of skin barrier function
CeraBEST® - Available as Cream & Lotion
Paraben Free
Alcohol Free
Soap Free
Animal Derived
Material Free
CeraBEST® is recommended
for usage in:
- Dry and scaly skin conditions
- For restoration of Skin Moisture and prevention of TEWL
- As an effective topical moisturizer for management of Atopic Dermatitis, Psoriasis and Acne prone skin
* – Recent advances on topical application of ceramides to restore barrier function; Emine Kahraman, Melis Kaykın, Hümeyra ¸ Sahin Bektay and Sevgi Güngör ; Cosmetics 2019, 6, 52; doi:10.3390/cosmetics6030052
